WRITTEN QUIZ BCAD GEN11US (PAEDIATRICS) WEEK 3

A. Fill in the blanks:

1.       Typically, Wilson disease is not clinically manifested before 3 to 5 years of age.

2.       2 commonest causes of neonatal cholestasis are idiopathic hepatitis and biliary atresia.

3.       Anti HBs is the only marker present in Hepatitis B-immunised person.

4.       Umbilical sepsis is the most common cause of pre-hepatic portal hypertension in infants.

5.       Early manifestation of post sinusoidal portal hypertension is ascites.

B. Matching:

Marker	Interpretation
1.       Anti-HBc IgM ( C )	A – Post vaccination
2.       Anti-HBs ( A )	B – High infectivity
3.       Anti-HBc IgG ( D  )	C – Recent infection
4.       HBsAg (  E  )	D – Past infection
5.       HBeAg (  B  )	E – Acute and chronic infection

C. Enumerate:

1. Enumerate intrahepatic causes of portal hypertension.

·         Congenital hepatic fibrosis

·         Bilharziasis

·         Cirrhosis (chronic hepatitis/Wilson disease)

·         Alpha -1- antitrypsin deficiency

·         Biliary atresia

·         Cystic fibrosis

·         Sclerosing cholangitis

2. Complications of chronic hepatitis.

·         Cirrhosis

·         Hepatocellular carcinoma

·         Portal hypertension, varices, ascites

·         Liver failure

·         Hepatic encephalopathy

3. Enumerate clinical manifestations of post-hepatic hypertension.

·         Ascites

·         Jaundice

·         Hepatosplenomegaly